![]() ![]() You could use days and fractional days if it occurs some hours apart within a day if you prefer with the long time frame of this study once you have got your records clarified I'm just used to dealing in hours for Clearance normally. Note I standardised to dose of ug and conc as ug/L to minimise confusion about units. please check this and update as necessary so you can see all the dose events explicitly in your work sheet, I have mocked this up for your first profile, assuming the doses and the samples were obtained at the same time each day e.g. your data look to be pretty sparse so I would propose modelling over NCA. You should use this to calculate a total elapsed time from FIRST dose and/or first dose within each month. You should have IMO, clear clock times for when your doses were, taken, just dates or days is not going to be very precise for estimation of anything. Earning professional certification through this new online accreditation program will validate scientists’ PK/PD data analysis skills using Certara software such as Phoenix WinNonlin and expand their professional reach. ![]() Lillian, I think your worksheet is too unclear/incomplete to work from.įirst off I imported your data, note the option to read units in the column header cell Lillian.jpg the demographics should probably be kept on every line for ease but the NLME tool can handle this as carry forward covariate if you prefer. Along with the Phoenix 8.1 release, Certara is introducing its Professional Certification Program through Certara University. ![]()
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